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Preparation of Chitosan-based Microspheres for Rapid Hemostasis
Received:November 17, 2020    Click here to download the full text
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Author NameAffiliation
Fang Yan Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007, China 
Li Peiyuan Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007, China 
Zhou Weikang Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007, China 
 
Abstract:Rapid control of heavy hemorrhaging is critical to save the life of injured individuals. Herein, we developed a novel hemostat employing chitosan-based microspheres, which was prepared by sequential microemulsion of chitosan solution, sol-gel phase transition, and surface modification by 3,4-dihydroxyhydrocinnamic acid (HCA). HCA-modified chitosan microspheres (CSMS-HCA) displayed a porous structure, with a high specific surface area (~211.3 m2/g), accelerating their rapid absorption of blood and concentrating red cells and platelets. The CSMS-HCA exhibited much better in vitro and in vivo hemostatic efficacy than porous chitosan microspheres did. Such a rapid hemostat in the form of microspheres is highly effective in treating deep and irregular wounds, owing to easy accessibility to injured sites.
keywords:chitosan  microspheres  hemostasis  wet-tissue adhesion
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