| Preparation of Chitosan-based Microspheres for Rapid Hemostasis |
| Received:November 17, 2020 Click here to download the full text |
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| Author Name | Affiliation | | Fang Yan | Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007, China | | Li Peiyuan | Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007, China | | Zhou Weikang | Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007, China |
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| Abstract:Rapid control of heavy hemorrhaging is critical to save the life of injured individuals. Herein, we developed a novel hemostat employing chitosan-based microspheres, which was prepared by sequential microemulsion of chitosan solution, sol-gel phase transition, and surface modification by 3,4-dihydroxyhydrocinnamic acid (HCA). HCA-modified chitosan microspheres (CSMS-HCA) displayed a porous structure, with a high specific surface area (~211.3 m2/g), accelerating their rapid absorption of blood and concentrating red cells and platelets. The CSMS-HCA exhibited much better in vitro and in vivo hemostatic efficacy than porous chitosan microspheres did. Such a rapid hemostat in the form of microspheres is highly effective in treating deep and irregular wounds, owing to easy accessibility to injured sites. |
| keywords:chitosan microspheres hemostasis wet-tissue adhesion |
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