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Surface Chemical Modification of Cellulose Nanocrystals and Its Application in Biomaterials
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Author NameAffiliation
XiaoZhou Ma1 1. School of Chemistry and Chemical Engineering, Joint International Research Laboratory of Bio-mass-Based Macromolecular Chemistry and Materials, Southwest University, Chongqing, 400715, China 
YanJie Zhang2 2. School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei Province, 430070, China 
Jin Huang1,2,* 1. School of Chemistry and Chemical Engineering, Joint International Research Laboratory of Bio-mass-Based Macromolecular Chemistry and Materials, Southwest University, Chongqing, 400715, China
2. School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei Province, 430070, China 
Fund Project:Jin Huang is grateful to the National Natural Science Foundation of China (51373131), Fundamental Research Funds for the Central Universities (XDJK2016A017, XDJK2016C033, and WUT-2014-II-009), Project of Basic Science and Advanced Technology Research, Chongqing Science and Technology Commission (cstc2016, jcyjA0796), and the Talent Project of Southwest University (SWU115034).
 
Abstract:Cellulose nanocrystals (CNCs) have been widely applied in biomaterials and show great biocompatibility and mechanical strength. In this review, the chemical reactions applied in CNC surface modification and their application in CNC based biomaterials are introduced. Furthermore, the conjugation of different functional molecules and nanostructures to the surface of CNCs are discussed, with focus on the binding modes, reaction conditions, and reaction mechanisms. With this introduction, we hope to provide a clear view of the strategies for surface modification of CNCs and their application in biomaterials, thus providing an overall picture of promising CNC-based biomaterials and their production.
keywords:cellulose nanocrystals  chemical modification  immobilization  biomaterials  application
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